How to save and transpose a range in Excel VBA - excel

Question

I have a macro where I open a textfile to copy and transpose several columns into my worksheet. As it is now this actually works. However, as I am right now opening the textfile, copying a column, going back to my original worksheet pasting and transposing the data, then switching back and forward between the two sheets until all relevant columns have been copied I figured it could probably be optimized if I understood VBA a little better.
So my question is if I can save the column data as ranges instead and then copying it all at once and pasting and transposing it all at once as well?
Or will this not have any impact on the speed of my macro?
Also, as I am actually opening many textfiles (open one, close it, open the next, close it, etc) is it possible to overwrite a range when a new textfile has been opened?
I have shown an example of my code below hope you can make sense of it:
'First Selection to be copied
ActiveSheet.Cells(RowTemp + 1, 1).Select
Range(Selection, Selection.End(xlDown)).Select
Selection.Copy
'Go back to original sheet
Windows(Left(f, Len(f))).Activate
'Paste and Transpose Data
If IsEmpty(ActiveSheet.Cells(4, 2).Value) = True Then
ActiveSheet.Cells(4, 1).Select
ActiveCell.Offset(0, 1).Range("A1").Select
Selection.PasteSpecial Paste:=xlPasteValues,
Operation:=xlNone, SkipBlanks _
:=False, Transpose:=True
ActiveSheet.Cells(4 + 5 + Range("A2").Value, 1).Select
ActiveCell.Offset(0, 1).Range("A1").Select
Selection.PasteSpecial Paste:=xlPasteValues,
Operation:=xlNone, SkipBlanks _
:=False, Transpose:=True
End If
'Copy 2nd set of Data
Windows(Left(z, Len(z))).Activate
Range("B1").Select
Selection.End(xlDown).Select
ActiveCell.Offset(1, 0).Range("A1").Select
Range(Selection, Selection.End(xlDown)).Select
Selection.Copy
Windows(Left(f, Len(f))).Activate
'Paste and Transpose 2. set of data
If IsEmpty(ActiveSheet.Cells(5, 2).Value) = True Then
ActiveSheet.Cells(5, 2).Select
Selection.PasteSpecial Paste:=xlPasteValues,
Operation:=xlNone, SkipBlanks _
:=False, Transpose:=True
ActiveSheet.Cells(5 + 5 + Range("A2").Value, 2).Select
Selection.PasteSpecial Paste:=xlPasteValues,
Operation:=xlNone, SkipBlanks _
:=False, Transpose:=True
End If