Unable to connect h2o server python3 - python-3.x

I have a problem trying to connect to the h2o server. The first time i'm able to do it. But the second time i get this error:
[18:56.78] H2OConnectionError: Unexpected HTTP error: HTTPConnectionPool(host='127.0.0.1', port=54321): Max retries exceeded with url: /3/Cloud (Caused by NewConnectionError('<urllib3.connection.HTTPConnection object at 0x7f3041303dd8>: Failed to establish a new connection: [Errno 111] Connection refused',))
At the begining of my script i have:
h2o.init(ip="127.0.0.1", port="54321")
I down know if the first time the connection didnt close. Any body can help me?
Thank you very much

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python3 request POST times out when calling Azure function app

I have a python program that reads a file and posts the data to an Azure function app. Over the past few weeks, I have started noticing this error in the logs. This program is about a year old and has never had an issue like this.
HTTPSConnectionPool(host=xxxx.azurewebsites.net', port=443): Max retries exceeded with url: /api/xxxx?code=zzzzzzzzzzz== (Caused by NewConnectionError('<urllib3.connection.HTTPSConnection object at 0x7ff96b5f0790>: Failed to establish a new connection: [Errno 110] Connection timed out'))
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Azure Custom Vision SDK - ClientRequestError

I am trying out an object detection project with the Custom Vision client library. But I get ClientRequestError. Below is my code:-
from azure.cognitiveservices.vision.customvision.training import CustomVisionTrainingClient
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from msrest.authentication import ApiKeyCredentials
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trainer = CustomVisionTrainingClient(credentials=credentials,endpoint=cv_endpoint)
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I get the below error:
ClientRequestError: Error occurred in request., ProxyError:
HTTPSConnectionPool(host='southcentralus.api.cognitive.microsoft.com',
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Seems there is something wrong with your cv_endpoint, If you have created a Custom Vision Training service in your subscription:
you can find the key and endpoint here:
This is my test result:

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I was using JIRA API for Python up until now to connect to JIRA, like so:
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jira = JIRA(options, basic_auth=('user', 'token'), max_retries=1)
However, since we moved from JIRA to JIRA DataCenter yesterday, this script doesn't work anymore. I get the following error message:
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I'd like to give it a try with crate. I first tried it by loading some twitter data and query from admin UI successfully. However, when I tried to make a query with SQLAlchemy, I've got the following error.
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No more Servers available, exception from last server: HTTPConnectionPool(host='localhost', port=4200):
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[SQL: SELECT * FROM tweets LIMIT 100; ]
(Background on this error at: http://sqlalche.me/e/e3q8)
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from crate import client
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query = (
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which caused the same error:
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Removed server http://127.0.0.1:4200 from active pool
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No more Servers available, exception from last server:
HTTPConnectionPool(host='127.0.0.1', port=4200):
Max retries exceeded with url:
/_sql (Caused by NewConnectionError('<urllib3.connection.HTTPConnection object at 0x7f5147faaa58>:
Failed to establish a new connection: [Errno 111] Connection refused'))
[SQL: SELECT * FROM tweets LIMIT 10; ]
(Background on this error at: http://sqlalche.me/e/e3q8)
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I am trying to call an API which used to work fine previously, suddenly it started to throw newConnectionError. How can I get this fixed?
I tried to run the same API on my local machine and on the test environment, working fine there.
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